Activités de recherche

 Principales études 2015 - 2016 :

Etudes institutionnelles : 

Cohort Study of Volunteers That Have Participated to Preventive HIV-1 Vaccine Trials (COHVAC, NCT00789789) ANRS »

* Multicenter Pilot Study Evaluating the Immunogenicity of an Innovative Pneumococcal Vaccination Strategy in Splenectomized Adults (SPLENEVAC, NCT02052154) APHP »

* Safety and Immunogenicity of Recombinant Pichia Pastoris AMA1-DiCo Candidate Malaria Vaccine With GLA-SE and Alhydrogel ® as Adjuvant in Healthy Malaria Non-Exposed European and Malaria Exposed African Adults (AMA1-DiCo, NCT02014727) »

Open Randomized Trial Evaluating Four Anti-pneumococcal Vaccine Strategies With Fractionated Doses of Non Conjugate Polysaccharide Vaccine to Prevent Hyporesponse in Healthy Volunteers (HYPOPNEUMO, NCT02279589) APHP »

Clinical Trial to Assess the Influenza Vaccination for Seasonal 2013-2016 (FLUVAC EV-03, NCT02027233) INSERM »

Vemurafenib and Cobimetinib Combination in BRAF Mutated Melanoma With Brain Metastasis (CONVERCE, NCT02537600) Center Eugene Marquis »

* Trial to Evaluate the Safety and Immunogenicity of a Placental Malaria Vaccine Candidate (PRIMVAC ) in Healthy Adults (PRIMALVAC, NCT02658253) INSERM »

GeneTB « Etude de l’influence de la génétique sur la prédisposition à la tuberculose » Institut Pasteur
Changing the coUrse of cRohn’s disease with an Early use of adalimumab:
The CURE study  Groupe d’Etude Thérapeutique des Affections Inflammatoires Digestives (G.E.T.A.I.D.)

ETUDE ANRS RF003 « IFN-VIH » Etude des sous types d’interférons de type I et de type
III produits par les cellules de sang périphérique de patients infectés par le VIH ANRS

ANRS RF 002 INTESTIPAX DESEQUILIBRE IL-23 /IL-12 ET POLARISATION t INTESTINALE DANS L’INFECTION PAR VIH IL-23/IL-12 Imbalance and T Lymphocyte Polarization in HIV Infection (INTESTIPAX) (NCT01942655) ANRS »


Essais industriels :

- A Study to Evaluate the Safety and Efficacy of Inactivated Varicella-zoster Vaccine (VZV) as a Preventative Treatment for Herpes Zoster (HZ) and HZ-related Complications in Adult Participants With Solid Tumor or Hematologic Malignancy (V212-011, NCT 01254630) Merck »

- Study to Evaluate the Safety and Efficacy of Two Different Dosing Schedules of Pembrolizumab (MK-3475) Compared to Ipilimumab in Participants With Advanced Melanoma (MK-3475-006/KEYNOTE-006, NCT01866319) Merck »

A Study of the BRAF Inhibitor Dabrafenib in Combination With the MEK Inhibitor Trametinib in the Adjuvant Treatment of High-risk BRAF V600 Mutation-positive Melanoma After Surgical Resection. (COMBI-AD) (NCT01682083) GSK »

- Safety, Tolerability and Immunogenicity Induced by the THV01 Treatment in Patients Infected With HIV-1 Clade B and Treated With Highly Active Antiretroviral Therapy (HAART). (NCT02054286)Theravectys S.A. »

- Study of a Candidate Clostridium Difficile Toxoid Vaccine (Cdiffense) in Subjects at Risk for C. Difficile Infection (NCT01887912) Sanofi Pasteur »

Open-label, Phase I/IIa Study of VAC-3S in HIV-1 Patients Who Showed an Immune Response to VAC-3S During IVVAC-3S/P1 (NCT02390466) InnaVirVax » 

Access Study of Trametinib for Subjects With Advanced Unresectable (Stage IIIc) or Distant Metastatic (Stage IV) BRAF V600E/K Mutation Positive Cutaneous Melanoma (NCT02416232) GSK »

Study of Pembrolizumab (MK-3475) Versus Placebo After Complete Resection of High-Risk Stage III Melanoma (MK-3475-054/KEYNOTE-054) (NCT02362594) Merck »

Safety and Efficacy of SA4Ag Vaccine in Adults Having Elective Open Posterior Spinal Fusion Procedures With Multilevel Instrumentation (STRIVE) (NCT02388165) Pfizer »

A Study to Assess Safety Tolerability and Immunogenicity of Three Prime-boost Regimens of the Candidate Prophylactic Vaccines for Ebola in Healthy Adults (NCT02416453) Crucell Holland BV »

A Study to Evaluate the Pharmacokinetics, Safety, and Antiviral Activity of JNJ-63623872 in Combination With Oseltamivir in Adult, and Elderly Hospitalized Participants With Influenza A Infection (NCT02532283) anssen Research & Development, LLC » 


Perspectives pour les 5 prochaines années :

  • Dans le cadre du partenariat avec l'Institut Pasteur, plusieurs essais vaccinaux sont prévus.

  • Le CIC est partenaire de 3 projets internationaux, financés par les Framework Programs de la Communauté Européenne.

  • Poursuite des recherches cliniques portant sur l'évaluation des vaccins, dans des populations fragiles. 

  • Développement de projets de recherche translationelle avec des équipes de recherche de l'Inserm, de l'Institut Pasteur et de l'Université Paris Descartes.pour mieux caractériser les réponses vaccinales. 



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